Empathy
Main ball spiker with a focus on C-target and single target damage thanks to 
EmpathyEmpathyMesmer / Domination Magic / Hex SpellE 10Cast 2Recharge 10For 5..15 seconds, whenever target foe attacks, that foe takes 10..55 damage and target foe deals 1..15 less damage with attacks. and 
Spiritual PainSpiritual PainMesmer / Domination Magic / SpellE 5Cast 1Recharge 7Target foe takes 15..75 damage. All hostile summoned creatures in the area of that foe take 25..125 damage..
Build
EmpathyMesmer / Necromancer
Me/N10 Domination Magic8 Fast Casting12 Curses
Spiteful SpiritElite / Necromancer / Curses / Hex SpellE 15Cast 2Recharge 10For 8..20 seconds, whenever target foe attacks or uses a skill, Spiteful Spirit deals 5..35 shadow damage to that foe and all adjacent allies of that foe.
Cry of PainMesmer / Sunspear rank / SpellE 10Cast 0.25Recharge 15Interrupt target foe's skill. If that foe was suffering from a Mesmer Hex, that foe and all foes in the area take 25..50 damage and -3..5 Health degeneration for 10 seconds.
Unnatural SignetMesmer / Domination Magic / SignetCast 1Recharge 10Target foe takes 15..75 damage. If that foe is under the effects of a hex or enchantment, foes adjacent to your target take 5..50 damage.Spiritual PainMesmer / Domination Magic / SpellE 5Cast 1Recharge 7Target foe takes 15..75 damage. All hostile summoned creatures in the area of that foe take 25..125 damage.
MistrustMesmer / Domination Magic / Hex SpellE 10Cast 2Recharge 12For 6 seconds, the next spell that target foe casts on one of your allies fails and deals 10..100 damage to that foe and all nearby foes.
"You Move Like a Dwarf!"Norn rank / ShoutE 10Recharge 10Target foe is knocked down and takes 44..80 damage. When that foe gets up, it is Crippled for 8..15 seconds.EmpathyMesmer / Domination Magic / Hex SpellE 10Cast 2Recharge 10For 5..15 seconds, whenever target foe attacks, that foe takes 10..55 damage and target foe deals 1..15 less damage with attacks.
Ebon EscapeEbon Vanguard rank / SpellE 5Cast 0.25Recharge 10Shadow Step to target other ally. You and that other ally are healed for 70..110 health.OQRDIKgHT5B2gmO4UTP2kaA0lGear
Use the shared Mesmer gear page as the baseline.
Titles
Required title tracks
Norn5
Lightbringer0A high lightbringer title is not Required but do not forget to activate it at Chantry of secrets. Pick up quest rewards and bounties in DoA to quickly level it up.
Recommended title tracks
Vanguard5Notes
- You are in charge of C-target, call for help when there are too many of them.
- Don't use EmpathyEmpathyMesmer / Domination Magic / Hex SpellE 10Cast 2Recharge 10For 5..15 seconds, whenever target foe attacks, that foe takes 10..55 damage and target foe deals 1..15 less damage with attacks. on Manks while doing City wall as it will reduce
Visions of RegretVisions of RegretElite / Mesmer / Domination Magic / Hex SpellE 10Cast 2Recharge 20For 10 seconds, target foe and adjacent foes take 15..45 damage whenever they use a skill and 5..50 damage if not under the effects of another Mesmer hex. damage, 
Energy SurgeEnergy SurgeElite / Mesmer / Domination Magic / SpellE 5Cast 2Recharge 15Target foe loses 1..10 Energy. For each point of Energy lost, that foe and all nearby foes take 9 damage., Unnatural SignetUnnatural SignetMesmer / Domination Magic / SignetCast 1Recharge 10Target foe takes 15..75 damage. If that foe is under the effects of a hex or enchantment, foes adjacent to your target take 5..50 damage. and Spiritual PainSpiritual PainMesmer / Domination Magic / SpellE 5Cast 1Recharge 7Target foe takes 15..75 damage. All hostile summoned creatures in the area of that foe take 25..125 damage. will be more optimal. - EmpathyEmpathyMesmer / Domination Magic / Hex SpellE 10Cast 2Recharge 10For 5..15 seconds, whenever target foe attacks, that foe takes 10..55 damage and target foe deals 1..15 less damage with attacks. is a powerful tool to deal with Jadoth in city or off-ball melees in foundry such as Ruk/Vu/Dementia.
- Leave the necromancer lord when he is at about 50% health after casting a last EmpathyEmpathyMesmer / Domination Magic / Hex SpellE 10Cast 2Recharge 10For 5..15 seconds, whenever target foe attacks, that foe takes 10..55 damage and target foe deals 1..15 less damage with attacks. on him.
- Avoid targeting warriors with your Energy SurgeEnergy SurgeElite / Mesmer / Domination Magic / SpellE 5Cast 2Recharge 15Target foe loses 1..10 Energy. For each point of Energy lost, that foe and all nearby foes take 9 damage. as they can run out of energy, reducing the damage.