IAU
Smiting spiker who covers left-side off-damage and the IAU tendril pair.
Build
Arcane EchoMesmer / Enchantment SpellE 15Cast 2Recharge 20If you cast a Spell in the next 20 seconds, Arcane Echo is replaced with that Spell for 20 seconds. Arcane Echo ends prematurely if you use a non-Spell skill.
Ray of JudgmentElite / Monk / Smiting Prayers / SpellE 10Cast 2Recharge 20For 5 seconds, target foe and all foes adjacent to this location take 5..45 holy damage each second and begin Burning for 1..3 seconds.
Symbol of WrathMonk / Smiting Prayers / SpellE 5Cast 2Recharge 30For 5 seconds, foes adjacent to the location in which the spell was cast take 8..32 holy damage each second.{self}
Mantra of ResolveMesmer / Inspiration Magic / StanceE 10Recharge 20For 30..90 seconds, you cannot be interrupted, but each time you would have been interrupted, you lose 10..4 Energy or Mantra of Resolve ends.
BanishMonk / Smiting Prayers / SpellE 5Cast 1Recharge 10Target foe takes 20..56 holy damage. This spell does double damage to summoned creatures.
"I Am Unstoppable!"Norn rank / ShoutE 5Recharge 30For 16..20 seconds, you have +24 armor and cannot be knocked down or Crippled.
"You Move Like a Dwarf!"Norn rank / ShoutE 10Recharge 10Target foe is knocked down and takes 44..80 damage. When that foe gets up, it is Crippled for 8..15 seconds.
Ebon EscapeEbon Vanguard rank / SpellE 5Cast 0.25Recharge 10Shadow Step to target other ally. You and that other ally are healed for 70..110 health.OwUT44BDHaJwn5eICgfgm0mkuEGear and consumables
Use the shared Smiter gear and the pcons listed there.
Titles
Norn5
Vanguard5Notes
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For tendrils, use
Arcane EchoArcane EchoMesmer / Enchantment SpellE 15Cast 2Recharge 20If you cast a Spell in the next 20 seconds, Arcane Echo is replaced with that Spell for 20 seconds. Arcane Echo ends prematurely if you use a non-Spell skill. → Ray of JudgmentRay of JudgmentElite / Monk / Smiting Prayers / SpellE 10Cast 2Recharge 20For 5 seconds, target foe and all foes adjacent to this location take 5..45 holy damage each second and begin Burning for 1..3 seconds. → Symbol of WrathSymbol of WrathMonk / Smiting Prayers / SpellE 5Cast 2Recharge 30For 5 seconds, foes adjacent to the location in which the spell was cast take 8..32 holy damage each second.{self} → "You Move Like a Dwarf!""You Move Like a Dwarf!"Norn rank / ShoutE 10Recharge 10Target foe is knocked down and takes 44..80 damage. When that foe gets up, it is Crippled for 8..15 seconds. on the back tendril. On the front tendril, have the caller apply 
Chaos StormChaos StormMesmer / Domination Magic / SpellE 5Cast 2Recharge 30Create a Chaos Storm at target foe's location that lasts for 10 seconds. Each second, foes adjacent to this location take 5..25 damage and lose 0..2 Energy, then use Ray of JudgmentRay of JudgmentElite / Monk / Smiting Prayers / SpellE 10Cast 2Recharge 20For 5 seconds, target foe and all foes adjacent to this location take 5..45 holy damage each second and begin Burning for 1..3 seconds., followed by "You Move Like a Dwarf!""You Move Like a Dwarf!"Norn rank / ShoutE 10Recharge 10Target foe is knocked down and takes 44..80 damage. When that foe gets up, it is Crippled for 8..15 seconds. and repeated BanishBanishMonk / Smiting Prayers / SpellE 5Cast 1Recharge 10Target foe takes 20..56 holy damage. This spell does double damage to summoned creatures. until it dies. Communicate with MT so they give you enough room with the back spawns on the pull. -
You handle off-damage throughout the run. Use
Mantra of ResolveMantra of ResolveMesmer / Inspiration Magic / StanceE 10Recharge 20For 30..90 seconds, you cannot be interrupted, but each time you would have been interrupted, you lose 10..4 Energy or Mantra of Resolve ends. to avoid interrupts. -
Pull and wall the last wave of 360. Use
Mantra of ResolveMantra of ResolveMesmer / Inspiration Magic / StanceE 10Recharge 20For 30..90 seconds, you cannot be interrupted, but each time you would have been interrupted, you lose 10..4 Energy or Mantra of Resolve ends. to spike; Seeder supports you with 
Healing SeedHealing SeedMonk / Healing Prayers / Enchantment SpellE 10Cast 2Recharge 25For 10 seconds, whenever target other ally takes damage, that ally and all adjacent allies gain 3..30 Health.{target}. -
Handle left-side off-damage at 6-0. If the ball is messy, also help with nearby main damage on the left: City, Fury, the Dementia wave 2 in room 4, and 6-0 after off-damage.
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On City wall, use one AoE on the first and last Mank and on every Su.